Description General description A murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134). Packaging 2 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Kd in low µM range Primary Target JNK Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂ Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327. Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.