Description General description The non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo. Packaging 2 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target JNK Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂ Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Guan, Q.H., et al. 2006. Neuroscience, 139, 609. Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327. Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550. Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.