Description Application Lenalidomide is a ligand demonstrated to bind the Cereblon (CRBN) protein. Lenalidomide, along with other thalidomide derivatives, are useful for constructing small molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. Explore protein degrader building blocks, E3 ligase ligand-linker conjugates that simplify the synthesis and library generation of PROTACs. . Other Notes Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins Legal Information PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license