Description_x000D_ General description_x000D_ Conjugated linoleic acid (CLA) describes the positional and geometric isomers of C18:2 fatty acids (FA) with a conjugated double bond. cis-9, trans-11 CLA are considered as the major isomers of CLA, based on in vitro experiments and animal studies in milk. The major source of CLA in human diet is the ruminant fat._x000D_ Application_x000D_ Linoleic acid, conjugated methyl ester (CLA) has been used as a standard for the determination of isomers of CLA in milk samples by high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry. It has also been used in the production of sn-1,3 diacyl glycerol._x000D_ Packaging_x000D_ 1 g in ampule_x000D_ 250 mg in ampule_x000D_ Biochem/physiol Actions_x000D_ Conjugated linoleic acid (CLA) isomers as supplements inhibit the growth of numerous human cancer cell lines. It also possesses immunostimulant properties, prevents diabetes and reduces atherosclerosis._x000D_ Other Notes_x000D_ A mixture of cis- and trans-9,11- and -10,12-octadecadienoic acid methyl esters. Isomer ratio may vary from lot to lot.