Description General description Lithium diisopropylamide solution (LDA) is a sterically hindered non-nucleophilic strong base widely used in organic synthesis. Application Lithium diisopropylamide solution (LDA) can be used: • As an initiator in the anionic polymerization of D,L-lactide and methyl methacrylate. • To facilitate ester enolization. • To convert carboxylic acids to enediolate intermediates for preparing trifluoromethyl ketones. • In ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs. • To catalyze ortholithiation and Fries rearrangement of aryl carbamates. • As a promoter in the isomerization of allylic ethers to (Z)-propenyl ethers. Packaging 4×25, 100, 4×100, 800 mL in Sure/Seal™ The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product. Legal Information Sure/Seal is a trademark of Sigma-Aldrich Co. LLC