Description_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ LSN2463359 is a selactive brain penetrant mGluR5 positive allosteric modulator. LSN2463359 is a potentiator of mGluR5-mediated Ca2+ influx in vitro, giving curve shifts 2 to 3 fold over agonist alone. In vivo, the compound exerts wake-promoting, cognitive and motor effects._x000D_ Features and Benefits_x000D_ This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.