Description_x000D_ Application_x000D_ Methyl-3,4-dephostatin has been used as:_x000D_ • an inhibitor for methyltransferases_x000D_ • a kinase-related inhibitor for human transglutaminase_x000D_ • a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein_x000D_ Biochem/physiol Actions_x000D_ Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI)._x000D_ Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.