Description_x000D_ Application_x000D_ Mefloquine hydrochloride has been used:_x000D_ • to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis_x000D_ • in screening for in vitro antischistosomal activity_x000D_ • in cytotoxicity assay of glioblastoma cells_x000D_ Packaging_x000D_ 100 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis._x000D_ Blocker of gap junction channels Cx36 and Cx50.