Description_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ MEL-3 is a potent androgen receptor antagonist from a new structural chemical class. MEL-3 has been shown to inhibit the proliferation of both androgen-dependent and androgen-independent AR-positive prostate cancer cell lines. MEL-3 was active against two mutant receptors (AR T877A and ARW741C) that have been found in patients who have become resistant to bicalutamide and hydroxyflutamide, two standard antiandrogens used in prostate cancer therapy._x000D_ Features and Benefits_x000D_ This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.