Description_x000D_ General description_x000D_ PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade._x000D_ Packaging_x000D_ 1 kg in poly bottle_x000D_ 10, 25 kg in poly drum_x000D_ 100 g in poly bottle_x000D_ Application_x000D_ MES Sodium is a biological buffer often referred to as a “Good’s” buffer. The pKa of MES is 5.96 which makes MES an ideal candidate for cell culture media and protein based buffer formulations to maintain a stable environment in solution. MES Sodium is considered to be non-toxic to culture cell lines, highly water soluble and provides high-solution clarity._x000D_ MES Sodium is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins and blood components._x000D_ Linkage_x000D_ Enhanced Quality Product Documentation on PharmaGrade MES Sodium Salt