Description General description Methyl indole-3-carboxylate (3-Methoxycarbonylindole, 3-Carbomethoxyindole, Methyl indolyl-3-carboxylate) has been extracted from the marine Streptomyces sp. 060524. Its crystal structure indicates the presence of inter­molecular N-H…O hydrogen bond. It is also obtained during the isolation of sorazinones A and B from Sorangium cellulosum strain Soce895. It undergoes regioselective dibromination with bromine in acetic acid to afford methyl 5,6-dibromoindole-3-carboxylate. Application Reactant for preparation of: • Nitric oxide synthase (nNOS) inhibitorS • Protein kinase c alpha (PKCα) inhibitors • Inhibitors of the C-terminal domain of RNA polymerase II as antitumor agents • Kinase insert domain receptor (KDR) inhibitors • Organocatalysts for the anti-Mannich reaction • Very late antigen-4 (VLA-4) antagonists • Inhibitors of Human 5-Lipoxygenase • Serotonin 5-HT4 receptor antagonists • Hyaluronidase inhibitors Reactant for: • Enantioselective Meerwein-Eschenmoser Claisen rearrangement reactions† Packaging 25 g in glass bottle