Description General description A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H2O2-, and glutamate-induced injury to mouse hippocampal HT22 cells. A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H2O2-, and glutamate-induced injury to mouse hippocampal HT22 cells. Packaging 50 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Progesterone and glucocorticoid receptors Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Carcinogenic / Teratogenic (D) Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes McCullers, D.L., et al. 2002. Neuroscience109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci.955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin.22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res.61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci.9, 912. Greb, R.R., et al. 1997. Hum. Reprod.12, 1280. Gruol, D.J., et al. 1994. Cancer Res.54, 3088.