Description_x000D_ Application_x000D_ Mifepristone has been used:_x000D_ • to induce damage against the proliferative and secretory phase of endometrial stromal cells_x000D_ • to establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs_x000D_ • to activate geneswitch gal4 in flies_x000D_ • to study the effects of sex steroids on prostaglandin secretion_x000D_ Packaging_x000D_ 1 g in glass bottle_x000D_ 100, 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Therefore, mifepristone is considered to be a potent abortifacient. It is also known to inhibit human chorionic gonadotropin. Mifepristone results in decidual necrosis._x000D_ Mifepristone (RU-486) has activity as both a progesterone receptor antagonist and a glucocorticoid receptor antagonist._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ This compound was developed by Danco Laboratories. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC