Description General description A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart. A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart. Packaging 10 mg in Alu drum Biochem/physiol Actions Cell permeable: yes Primary Target PDE 3 Product does not compete with ATP. Reversible: no Target IC50: 300 nM against PDE III Warning Toxicity: Toxic (F) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C. Other Notes Bailey, J.M., et al. 1994. Anesthesiology 81, 616. Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705. Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209. Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.