Description_x000D_ General description_x000D_ The ready-to-use MISSION miRNA mimics are small, double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules when introduced into cells. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation. MISSION miRNA Mimics, a member of MISSION RNAi product family, provides miRNA researchers with a range of options from individual MISSION mimics to a full library of human miRNA mimics based on latest version of miRBase (currently hosted by the University of Manchester, previously hosted by the Sanger Institute)._x000D_ • Optimized and ready for transfection._x000D_ • Novel MISSION miRNA mimic design has been functionally tested for knockdown efficiency against natural miRNA targets._x000D_ • Unique MISSION miRNA mimic design significantly reduces possible sense strand off target effects._x000D_ • Available as a whole human library and individual miRNA targets._x000D_ Biochem/physiol Actions_x000D_ The miRNA hsa-miR-155-5p is a hypoxia-inducible oncomir which particularly targets the 3′UTR of the HIF1α (hypoxia-inducible factor 1-α) mRNA. It also targets pVHL (von Hippel Lindau tumour suppressor protein), thereby controlling hypoxic response pathways. The miRNA hsa-miR-155-5p controls ELK3 (ETS domain-containing protein) expression under hypoxia. It also regulates the expression of TFAM (transcription factor A, mitochondrial) and thereby regulates mitochondrial biogenesis in diploid cells. The miRNA hsa-miR-155-5p is upregulated in active MS (multiple sclerosis) lesions._x000D_ Other Notes_x000D_ miRBase V18 Mature ID update: hsa-miR-155-5p_x000D_ Legal Information_x000D_ MISSION is a registered trademark of Sigma-Aldrich Co. LLC