Description General description A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase. A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase. Packaging 10 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target MMP-1, MMP-8 Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Sequence 4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl] Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Other Notes Hagemamn, T., et al. 2004. Carcinogenesis25, 1543. Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.