Description_x000D_ Immunogen_x000D_ Immunogen Description: Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin_x000D_ Immunogen Region: C-terminal_x000D_ Immunogen Species: Human_x000D_ Immunogen type: Fusion protein_x000D_ Application_x000D_ Western blotting_x000D_ Dilution 1:1000_x000D_ Tissue/Cell Type Used: monkey COS-Beta-4-Spectrin-His_x000D_ Immunofluorescence_x000D_ Dilution 1:100_x000D_ Tissue/Cell Type Used: SK-N-BE_x000D_ Physical form_x000D_ 50% glycerol, 0.1% sodium azide_x000D_ PBS pH 7.4_x000D_ Storage and Stability_x000D_ Protect from light; avoid repeated freeze-thaw cycles. Store at -20 °C long-term, 2-8 °C short-term._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Preparation Note_x000D_ Derived from animal serum_x000D_ Other Notes_x000D_ Additional Product Details:_x000D_ Does not cross react with other Beta-spectrins_x000D_ Lot Expiration/Retest Date: Expires 1 year from purchase_x000D_ Target/Gene Description: Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart . Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier ._x000D_ Purification method: Protein G purified_x000D_ Product type: Primary antibody_x000D_ Antibody structure: Whole Antibody_x000D_ Protein ID: NP_066022.2