Description_x000D_ General description_x000D_ Chromosome 17 open reading frame 28 (C17orf28) or downregulated in multiple cancer-1 (DMC1) is an integral membrane protein of 788 amino acids. The protein comprises of an N-terminal cytoplasmic domain, a single transmembrane peptide and a C-terminal extracellular domain. It is located on human chromosome 17q25.1._x000D_ Immunogen_x000D_ C17orf28 purified recombinant protein_x000D_ Physical form_x000D_ Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide._x000D_ Biochem/physiol Actions_x000D_ Chromosome 17 open reading frame 28 (C17orf28) or downregulated in multiple cancer-1 (DMC1) functions as a potential tumor suppressor. Absence of this gene leads to cancer in tissues of breast, cervix, liver and lung.