Description_x000D_ General description_x000D_ The gene CACNB1 (calcium voltage-gated channel auxiliary subunit β 1) encodes a member of the calcium channel β subunit family. The gene spanning a length of 25kb contains 13 exons and is mapped to human chromosome 17. Alternative splicing at exons 7 and 13 produces β1a,β1b and βlc isoforms._x000D_ Specificity_x000D_ Detects ~80, 55 kDa. No cross-reactivity against Cav Beta4_x000D_ Immunogen_x000D_ Synthetic peptide amino acids 19-34 of rat CavB1, Accession Number NP_059042_x000D_ Physical form_x000D_ Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The gene CACNB1 (calcium voltage-gated channel auxiliary subunit β 1) encodes the human brain β1 subunit of voltage dependent calcium channels called dihydropyridine receptors (DHPR). They detect changes in membrane voltage by activating ryanodine receptors to release Ca2+ from the sarcoplasmic reticulum into the cytosol, leading to excitation–contraction (EC) coupling._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.