Description_x000D_ General description_x000D_ Integrin subunit α M (ITGAM), also known as cluster of differentiation 11 antigen-like family member B (CD11b), belongs to integrin α chain family. The rat monoclonal antibody M1/70 detects CD11b (integrin αM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions. In human chromosome, the gene ITGAM is localized on 16p11.2._x000D_ Immunogen_x000D_ B10 mouse spleen cells enriched for T cells_x000D_ Application_x000D_ The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. Monoclonal Anti-CD11b-FITC antibody produced in rat has been used in fluorescence-activated cell sorting (FACS) analysis._x000D_ Physical form_x000D_ Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Integrin subunit α M (ITGAM) combines with b2 chain (ITGB2) and forms leukocyte integrin, which is commonly referred as macrophage 1 antigen (MAC-1) or complement receptor 3 (CR3), which is essential for adherence of neutrophils and monocytes to stimulated endothelium. ITGAM is a receptor for the degradation product of complement C3 degradation product (iC3b), intracellular adhesion molecule 1 (ICAM1) and fibrinogen. ITGAM participates in adhesion and phagocytosis. Polymorphism in ITGAM is associated with autoimmune diseases like systemic lupus erythematosus. Single nucleotide polymorphism (SNP) in ITGAM is also related to discoid lupus erythematosus (DLE) and systemic scleroderma. ITGAM is implicated in the regulation of acute myeloid leukemia._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.