Description_x000D_ General description_x000D_ Monoclonal Anti-CHD5 (rat IgG2a isotype) is derived from the hybridoma 5A10 produced by the fusion of mouse myeloma cells and lymph node cells from rat immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of human CHD5. Chromodomain helicase DNA(CHD) binding protein 5 (CHD5) is an ATP-dependent chromatin-remodeling factor. It is mainly expressed in neuronal tissues. CHD5 is a member of CHD family of proteins that is characterized with histone binding chromo (chromatin organization modifier) domains and sucrose non-fermentable 2 (SNF2)-related helicase/ATPase domains._x000D_ Immunogen_x000D_ synthetic peptide corresponding to a sequence at the C-terminal region of human CHD5 ._x000D_ Application_x000D_ Monoclonal Anti-CHD5 antibody produced in rat has been used in various immunochemical techniques including:_x000D_ • immunoblotting_x000D_ • flow cytometry_x000D_ • immunocytochemistry_x000D_ • immunohistochemistry_x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Chromodomain helicase DNA binding protein 5 (CHD5) regulates genes involved in neuronal function, cell-cycle control, and chromatin remodeling. Interestingly, CHD5 is frequently deleted in neuroblastoma and thus suggested as a tumor suppressor gene. Furthermore, non-conformist CHD5 promoter methylation was identified in several primary tumors.