Description_x000D_ General description_x000D_ Monoclonal Anti-Dystrophin (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Dystrophin is a structural protein on the inner face of the membrane, consisting of a 25-repeat, rod-like, triple-helical domain separating an N-terminal actin binding domain from two C-terminal domains, one of which is rich in cysteine._x000D_ Immunogen_x000D_ recombinant human dystrophin fragment._x000D_ Application_x000D_ Monoclonal Anti-Dystrophin antibody produced in mouse has been used in_x000D_ • immunohistochemistry_x000D_ • immunofluorescence_x000D_ • double immunofluorescence terminal dUTP nick-end labeling (TUNEL)_x000D_ • immunoblotting_x000D_ Target description_x000D_ The rod domain of the human dystrophin molecule is present in normal muscle tissue and in nearly all Becker muscular dystrophies. It is absent in the cases of Duchenne muscular dystrophies and in the dystrophic mouse (mdx)._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Dystrophin deficiency is associated with severe Duchenne muscular dystrophy (DMD). Becker muscular dystrophy (BMD) show less pronounced abnormalities of dystrophin protein expression. Since abnormalities in the protein expression occur specifically in patients with these types of muscular dystrophy, dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases._x000D_ Other Notes_x000D_ This product can be found as purified product that was produced using cell culture hybridoma product._x000D_ SAB4200764 Anti-Dystrophin antibody, Mouse monoclonal_x000D_ clone MANDYS8, purified from hybridoma cell culture