Description_x000D_ General description_x000D_ Monoclonal Anti-Human IgG (Fc specific) (mouse IgG1 isotype) is derived from the GG-7 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment._x000D_ Immunogen_x000D_ Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads_x000D_ Application_x000D_ Monoclonal Anti-Human IgG (Fc specific) antibody has been used in:_x000D_ • ELISA_x000D_ • Imprint Immunofixation (IIF)_x000D_ • Immunofluorometric Assay (IFMA)_x000D_ • Hemagglutination (HA)_x000D_ • Hemagglutination Inhibition (HAI)_x000D_ • Particle Counting Immunoassay (PACIA)_x000D_ • detection of cytoplasmic IgG_x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The crystallizable fragment (Fc) of IgG has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. IgG deficiencies are often associated with various diseases.