Description_x000D_ General description_x000D_ Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons._x000D_ Specificity_x000D_ Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp._x000D_ Immunogen_x000D_ MDR3 P-gp (amino acids 629-692) GST fusion protein._x000D_ Physical form_x000D_ Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.