Description_x000D_ General description_x000D_ Monoclonal Anti-Ornithine Decarboxylase (ODC) (mouse IgG2b isotype) is derived from the ODC-29 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Its amino acid sequence is well conserved among species; the overall identity of the amino acid sequences of mouse, rat and human ODC proteins is greater than 90%._x000D_ Ornithine decarboxylase (ODC) levels increase rapidly after implantation during mouse embryogenesis. The gene encoding this protein is localized on mouse chromosome 12 and human chromosome 2._x000D_ Specificity_x000D_ By immunohistochemical staining of formalin-fixed, paraffin-embedded human prostate and colon carcinoma, the labeling is confined to epithelial cells._x000D_ Immunogen_x000D_ recombinant mouse ornithine decarboxylase._x000D_ Application_x000D_ Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse has been used in Western blotting._x000D_ Monoclonal Anti-Ornithine Decarboxylase (ODC) has also been used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation, immunoblotting and immunohistochemistry._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Ornithine Decarboxylase (ODC) biological activity is rapidly induced to promote cell proliferation in response to hormones, drugs, growth factors, mitogens and tumour promoters. ODC mRNA levels are also elevated in transformed cells including lung carcinomas and human colon adenomas and carcinomas. ODC activity in colorectal carcinomas has been shown to be greater than that in adenomas, which, in turn, is greater than that of normal mucosa. ODC has a half-life of 8-30 min, the shortest half-life time reported in eukaryotic cells._x000D_ Ornithine decarboxylase (ODC) converts L-ornithine to putrescine. It has a role in cell replication. ODC is also involved in the polyamine synthesis pathway. The protein is upregulated in cancers. Overexpression of ODC has been associated with carcinogenesis in mice.