Description_x000D_ Immunogen_x000D_ Recombinant protein encoding amino acids 1-140 of the large subunit of human DNA polymerase d._x000D_ Application_x000D_ For WB: Use at a concentration of 1:1,000. Predicted molecular weight: 130 kDa. Optimal dilutions/concentrations should be determined by the reseracher._x000D_ Physical form_x000D_ Phosphate-buffered saline, pH 7.2, containing no preservatives_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ DNA polymerase d (delta) functions in DNA replication and DNA repair. It also possesses 3′ to 5′ exonuclease activity. In leading strand synthesis it requires the processivity factor, PCNA. It is also possibly involved in the completion of DNA synthesis during Okazaki fragment elongation following the initiation of synthesis by the DNA polymerase a/primase complex_x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.