Description_x000D_ General description_x000D_ PTPRE (Protein tyrosine phosphatase, receptor type, E) is a transmembrane protein consisting of a short extracellular domain and two tandemly repeated intracellular PTPase domains. It is located on chromosome 10q26 in humans. It is expressed in testis, brain, lung and lymph node. Its expression also has been observed during neuronal differentiation and in murine mammary tumour cells. It has an isoform consisting of an N-terminal catalytic, active phosphatase domain 1 (PD1)._x000D_ Immunogen_x000D_ PTPRE purified recombinant protein_x000D_ Application_x000D_ Monoclonal Anti-PTPRE antibody produced in mouse is suitable for western blot assay._x000D_ Physical form_x000D_ Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide._x000D_ Biochem/physiol Actions_x000D_ PTPRE (Protein tyrosine phosphatase, receptor type, E) is associated with various signalling pathways including down regulation of insulin receptor signalling and Janus kinase (Jak)-STAT inhibition signalling pathway. It also plays an important role in the regulation of ERK1/2 pathway by emerging as a phosphatase through its catalytic activity. Study shows that it may play an accessory role in tumour development.