Description_x000D_ General description_x000D_ Sorbin and SH3 domain-containing protein 1 (SORBS1) is also called c-Cbl-associated protein (CAP) or ponsin. The SORBS1 gene is located on human chromosome 10q24.1. SORBS1 has sorbin homology domain (SOHO) and three SH3 (sarcomahomology 3) domains._x000D_ Immunogen_x000D_ Synthetic peptide corresponding to an internal sequence of human SORBS1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2)._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Sorbin and SH3 domain-containing protein 1 (SORBS1) modulates cell adhesion by interacting with cytoskeletal proteins. It regulates glucose uptake. Polymorphisms in SORBS1 is implicated in obesity, insulin resistance, type 2 diabetes and diabetic nephropathy. It suppresses tumorigenesis by modulating c-Jun N-terminal kinases (JNKs) of mitogen-activated protein kinase (MAPK) signaling pathway in lung and breast cancers.