Description_x000D_ General description_x000D_ This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq_x000D_ Immunogen_x000D_ Recombinant Flag fusion protein corresponding to amino acids 25-302 of human STC2._x000D_ Mouse monoclonal antibody raised against stanniocalcin-2._x000D_ Physical form_x000D_ Solution in phosphate buffered saline, pH 7.4