Description_x000D_ Application_x000D_ 3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:_x000D_ • to inhibit collagen cross-linking during microtissue formation and culture_x000D_ • in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay_x000D_ • in lysyl oxidase (LOX) activity assay_x000D_ • to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids_x000D_ Packaging_x000D_ 5, 10, 25 g in poly bottle_x000D_ Biochem/physiol Actions_x000D_ 3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking._x000D_ In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC