Description_x000D_ General description_x000D_ Monoclonal anti-β-2-Microglobulin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse._x000D_ β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily. β−2-Microglobulin is a membrane glycoprotein of mammalian nucleated cells including lymphocytes._x000D_ Immunogen_x000D_ human β2-microglobulin and a lysate of a lymphoblastoid cell line._x000D_ Application_x000D_ Monoclonal Anti-β2-Microglobulin antibody produced in mouse has been used in ELISA and immunofluorescent labelling._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Microglobulin may be elevated in the serum or urine of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, metal toxications, some viral infections and possibly malignant disorders and AIDS._x000D_ β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis. It may function as a structural part of the MHC Class I molecule.