Description_x000D_ General description_x000D_ Tumor Necrosis Factor α (TNF-α) is a proinflammatory cytokine. It is a transmembrane protein and the final protein is devoid of the extracellular domain. TNF-α-converting enzyme (TACE) catalyzes the formation of the soluble homotrimer TNF-α._x000D_ Immunogen_x000D_ Recombinant Mouse TNF-α_x000D_ Application_x000D_ Mouse Tumor Necrosis Factor α ELISA Kit has been used in measuring TNF-αin MC3T3-E1 murine preosteoblastic calvarial cell lines, rat serum, mice liver and kidney samples._x000D_ Biochem/physiol Actions_x000D_ Tumor Necrosis Factor α (TNF-α) elicits inflammatory and immuno-regulatory functionality. It mediates its effects via its receptors TNFR1 and TNFR2._x000D_ Other Notes_x000D_ A sample Certificate of Analysis is available for this product._x000D_ Please type the word sample in the text box provided for lot number.