Description_x000D_ General description_x000D_ Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da._x000D_ Myelin basic protein (MBP), an important constituent of the myelin sheath of CNS (central nervous system). It is an autoimmunogen. MBP is mapped to human chromosome 18q._x000D_ Application_x000D_ Myelin Basic Protein from guinea pig brain has been used as a component in emulsion to induce experimental autoimmune encephalitis (EAE)._x000D_ Packaging_x000D_ 1, 5 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis._x000D_ Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme._x000D_ Quality_x000D_ May contain traces of urea-glycine buffer salts._x000D_ Principle_x000D_ Used as a kinase substrate.