Description_x000D_ Application_x000D_ Nω-Nitro-L-arginine methyl ester hydrochloride has been used:_x000D_ • to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons_x000D_ • to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin_x000D_ • to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells_x000D_ • to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat_x000D_ Packaging_x000D_ 1, 5, 10, 25 g in poly bottle_x000D_ 250 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC