Description_x000D_ General description_x000D_ Neuraminidase, also known as Sialidase, is an enzyme that hydrolyzes terminal sialic acid residues on poly-saccharide chains. It is predominantly expressed in microorganisms such as bacteria and viruses. Cleavage of sialic acid residues by neuraminidase is believed to play several roles in infection by influenza viruses. It is thought to assist in the penetration of mucosal linings, the invasion of target cells, the elution of progeny viruses from infected cells, and the prevention of self-aggregation. Thus, neuraminidase is an important target for influenza drug development and simple, direct, and automation-ready procedures for measuring neuraminidase activity find wide applications in research and drug discovery._x000D_ Features and Benefits_x000D_ Compatible with high-throughput handling systems._x000D_ Suitability_x000D_ Suitable for the detection of neuraminidase activity in biological samples and for the screening of neuraminidase inhibitors._x000D_ Principle_x000D_ In this assay, neuraminidase activity is determined by an enzymatic assay in which sialic acid released by neuraminidase results in a colorimetric (570 nm)/fluorometric (λex = 530/λem = 585 nm) product directly proportional to neuraminidase activity in the sample. The linear detection range at 37 °C is 0.1-10 units/L for colorimetric assays and 0.01-2 units/L for fluorometric assays.