Description General description Potent hypothalamic peptide neurotransmitter. An endogenous anti-psychotic compound that lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone and prolactin in rats. A modulator of noradrenergic activity. Heterogeneously distributed in the mammalian central nervous system and has many neurotransmitter-like characteristics. Potent hypothalamic peptide neurotransmitter. Lowers blood pressure, increases vascular permeability and increases plasma levels of glucagon, glucose, growth hormone and prolactin in rats. A modulator of noradrenergic activity. Heterogeneously distributed in the mammalian central nervous system and has many neurotransmitter-like characteristics. Biochem/physiol Actions Cell permeable: no Primary Target Modulator of noradrenergic activity Product does not compete with ATP. Reversible: no Packaging Yes Warning Toxicity: Standard Handling (A) Sequence Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH Other Notes Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340. Tyler, B.M., et al. 1998. Brain Res. 792, 246. Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.