Description_x000D_ General description_x000D_ NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family. This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues._x000D_ Application_x000D_ Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells._x000D_ Biochem/physiol Actions_x000D_ Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia._x000D_ Physical form_x000D_ Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine._x000D_ Analysis Note_x000D_ The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.