Description_x000D_ Application_x000D_ Nutlin-3 has been used:_x000D_ • as a drug to stimulate p53 functions in gene transfer experiment_x000D_ • to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae_x000D_ • as a p53 activator in cyclotherapy studies_x000D_ • as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage_x000D_ Packaging_x000D_ 1, 5 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73._x000D_ Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer._x000D_ Features and Benefits_x000D_ This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Other Notes_x000D_ Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers._x000D_ Analysis Note_x000D_ relative stereochemistry_x000D_ Legal Information_x000D_ Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302.