Description_x000D_ Amino Acid Sequence_x000D_ Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]_x000D_ Application_x000D_ Powerful probe for exploring the vertebrate pre-synaptic terminal._x000D_ ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies._x000D_ Biochem/physiol Actions_x000D_ Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L._x000D_ ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities._x000D_ Other Notes_x000D_ Lyophilized from 0.1% TFA in H2O