Description_x000D_ General description_x000D_ Chemical structure: aminoglycoside_x000D_ Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon._x000D_ Application_x000D_ • Paromomycin sulfate salt has been used as a:_x000D_ • reference compound in antileishmanial activity_x000D_ • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex._x000D_ Recommended for use in cell culture applications at 100mg/L._x000D_ Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI)._x000D_ Biochem/physiol Actions_x000D_ Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death._x000D_ Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc._x000D_ Other Notes_x000D_ 1g,5g_x000D_ Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place