Description General description A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes. A cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes. Packaging 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Calpain-1 Product does not compete with ATP. Reversible: no Target Ki: 210 nM for calpain-1 and 370 nM for calpain-2 Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Other Notes Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539. Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960. Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150. Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.