Description_x000D_ Application_x000D_ Penitrem A has been used as Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons._x000D_ Packaging_x000D_ 1, 5 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum._x000D_ Features and Benefits_x000D_ This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ Other Notes_x000D_ Originally isolated from Penicillium palitans