Description_x000D_ Application_x000D_ Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors ._x000D_ Biochem/physiol Actions_x000D_ PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis ._x000D_ Physical properties_x000D_ N-terminal GST-tagged 126 kDa full-length protein_x000D_ Unit Definition_x000D_ One unit will convert 1.0 picomole of 3′,5′-cGMP to 5′-GMP per minute at pH 7.4 at 37 °C._x000D_ Physical form_x000D_ Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN® 20 and 3 mM DTT_x000D_ Legal Information_x000D_ TWEEN is a registered trademark of Croda International PLC