Description_x000D_ Application_x000D_ Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP. Product P3134 is from crude, dried Crotalus adamanteus venom._x000D_ Phosphodiesterase I from Crotalus adamanteus venom has been used:_x000D_ • for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers_x000D_ • as a model for the hydrolysis of prodrugs in phosphodiesterase assay_x000D_ • as a component in the nucleotide cleavage buffer_x000D_ Biochem/physiol Actions_x000D_ Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.