Description General description A potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl– channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin. A potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl- channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin. Biochem/physiol Actions Cell permeable: no Primary Target GABA receptors Product does not compete with ATP. Reversible: no Target IC50: 240 nM against GABA receptors Warning Toxicity: Highly Toxic (H) Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299. Yoon, K.W., et al. 1993. J. Physiol.464, 423. Akaike, N., et al. 1985. Experientia41, 70.