Description General description A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent. A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent. Packaging 10 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target human telomerase Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Harmful & Carcinogenic / Teratogenic (E) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C. Other Notes Han, H., et al. 1999. Biochemistry38, 6981. Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.