Description_x000D_ General description_x000D_ PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce three isoforms in humans namely, PLGF1, PLGF2 and PLGF3._x000D_ Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains._x000D_ Biochem/physiol Actions_x000D_ PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes._x000D_ Physical form_x000D_ Sterile filtered and lyophilized with no additives._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Avoid freeze-thaw cycles._x000D_ Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer.