Description_x000D_ General description_x000D_ Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation._x000D_ Application_x000D_ Poly-L-histidine has been used:_x000D_ • as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)_x000D_ • as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane_x000D_ • in screening its anti-prion activity in cell based and in vivo anti-prion assay_x000D_ Packaging_x000D_ 10, 50, 100 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment._x000D_ Analysis Note_x000D_ Molecular weight by MALLS._x000D_ Other Notes_x000D_ For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.