Description General description Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H2O (Cat. No. 508573). Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme. Packaging 10 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Plasma and glandular kallikreins Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Sequence H-D-Phe-Pro-Arg-chloromethylketone, 2TFA Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C. Other Notes Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109. Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217. Gibson, T.R., et al. 1987. Endocrinology120, 764. Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.