Description_x000D_ Application_x000D_ Probenecid has been used:_x000D_ • as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay_x000D_ • as a component of calcium sensitive dye for calcium mobilization Studies_x000D_ • as a supplement in Hank′s balanced salt solution (HBSS) assay buffer_x000D_ Biochem/physiol Actions_x000D_ Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma._x000D_ Features and Benefits_x000D_ This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Other Notes_x000D_ Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P8761.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.